Molecular forms of ruminant BMP15 and GDF9 and putative interactions with receptors
نویسندگان
چکیده
منابع مشابه
Signalling pathways mediating specific synergistic interactions between GDF9 and BMP15.
Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are two proteins selectively expressed in the oocyte which are essential for normal fertility. Both of these proteins are members of the transforming growth factor beta (TGF-β) superfamily and as such are produced as pre-proproteins, existing after proteolytic processing as a complex of the respective pro and matur...
متن کاملBMP15 and GDF9 Gene Mutations in Premature Ovarian Failure
BACKGROUND Premature ovarian failure (POF) is an ovarian defect characterized by the premature depletion of ovarian follicles before the age of 40, representing one major cause of female infertility. Mutations in bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) have been shown to be associated with POF. METHODS Genomic DNA was isolated from 52 idiopathic premat...
متن کاملa comparison of teachers and supervisors, with respect to teacher efficacy and reflection
supervisors play an undeniable role in training teachers, before starting their professional experience by preparing them, at the initial years of their teaching by checking their work within the proper framework, and later on during their teaching by assessing their progress. but surprisingly, exploring their attributes, professional demands, and qualifications has remained a neglected theme i...
15 صفحه اولP-219: GDF9, BMP15 and Their Receptors Expression During In Vitro Culture of Mouse Vitrified Ovarian Tissue Derived Preantral Follicles
Background: In vitro culture (IVC) of isolated preantral follicles from cryopreserved ovarian tissue might be an efficient method for enhancing mature oocytes in patients who are exposed to infertility. Materials and Methods: Ovaries of 13-day old NMRI mice were removed and randomly placed into control,needle immersed (NIV) and solid surface vitrification (SSV) groups. For vitrification, ovarie...
متن کاملMutations and sequence variants in GDF9 and BMP15 in patients with premature ovarian failure.
BACKGROUND AND OBJECTIVE Mutations in bone morphogenic protein 15 (BMP15) and growth/differentiation factor 9 (GDF9) lead to altered fertility in animal models. In the human, a heterozygous point mutation of BMP15 has been associated with premature ovarian failure (POF). SUBJECT AND METHODS We have directly sequenced both genes in a cohort of 203 POF patients presenting with primary or second...
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ژورنال
عنوان ژورنال: Reproduction
سال: 2017
ISSN: 1470-1626,1741-7899
DOI: 10.1530/rep-17-0188